BMY-14802 hydrochloride( —— )

Catalog No. M33835 CAS No. 105565-55-7

BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adrenergic receptor and 5-HT1A.

Purity : >98% (HPLC)

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Size	Price / USD	Stock	Quantity
5MG	40	Get Quote
10MG	65	Get Quote
25MG	134	Get Quote
50MG	228	Get Quote
100MG	334	Get Quote
200MG	474	Get Quote
500MG	Get Quote	Get Quote
1G	Get Quote	Get Quote

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Biological Information

Product Name

BMY-14802 hydrochloride
Note

Research use only, not for human use.
Brief Description

BMY-14802 hydrochloride (BMS 181100 hydrochloride) is a selective antagonist of σ receptor (IC50 = 112 nM) with antipsychotic effects. BMY-14802 hydrochloride is an agonist of the α1-adrenergic receptor and 5-HT1A.
Description

BMY-14802 hydrochloride (BMY-14802-1) is a selective and orally active sigma receptor antagonist with an IC50 of 112 nM. BMY-14802 hydrochloride is also a 5-HT1A and adrenergic α1 receptors agonist. BMY-14802 hydrochloride has antipsychotic effects.
In Vitro

Similar to other 5-HT1A agonists, BMY-14802 hydrochloride affects the firing of 5-HTergic and catecholaminergic neurons and affects behaviors mediated by 5-HT in a 5-HT1A-sensitive manner. BMY-14802 hydrochloride is devoid of significant affinity for the D2 receptor.
In Vivo

BMY-14802 (5 mg/kg, 10 mg/kg or 20 mg/kg, ip; once) hydrochloride shows anti-dyskinetic efficacy across a 4-fold dose range against L-DOPA-induced dyskinesias (LID) and is also effective in reducing D1 and D2 receptor agonist-induced dyskinesias. Importantly, at anti-LID doses, BMY-14802 hydrochloride does not affect the efficacy of L-DOPA against lesion-induced akinesia.
Synonyms

——
Pathway

GPCR/G Protein
Target

5-HT Receptor
Recptor

5-HT Receptor | Sigma receptor | Adrenergic Receptor
Research Area

——
Indication

——

Chemical Information

CAS Number

105565-55-7
Formula Weight

384.85
Molecular Formula

C18H23ClF2N4O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (324.80 mM; Ultrasonic )
SMILES

Cl.OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. J P Yevich, et al. Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J Med Chem. 1992 Nov 27;35(24):4516-25.?

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